Werner Treptow
Werner has a B.S. degree in Biology (1998), Ph.D in Molecular Biology (University of Brasilia, 2003) and Ph.D. in Theoretical and Computational Chemistry (University Henri Poincaré, 2004). He was a postdoctoral scholar in the laboratory of Prof. Mounir Tarek at the University Henri-Poincaré in France and in the laboratory of Prof. Michael L Klein at the University of Pennsylvania in the US. After his postdoctoral training, he joined the University of Brasilia in Brazil (2009) as an Associate Professor of Computational Molecular Biophysics. Since then, he has worked in the research field of structure, function and regulation of membrane proteins, he has trained graduate students and postdoctoral scholars, in addition to establishing international collaborations as a visiting Professor at the Institute for Computational Molecular Sciences at Temple University (2012-2013) and at the Gordon Center for Integrative Sciences at the University of Chicago (2021-2023). He has extensively worked as a reviewer for scientific journals and more recently, he became an Associate Editor in Frontiers in Cellular Neuroscience.
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Selected Papers
Isoleucine gate blocks K+ conduction in C-type inactivation
Werner Treptow, Yichen Liu, Carlos A.Z. Bassetto, Bernardo I. Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J. Chipot, Francisco Bezanilla, Benoit Roux, (2024), eLife sciences.
Allosteric modulation of membrane proteins by small low-affinity ligands
Treptow W (2023). J. Chem. Inf. Model..
Cirqueira L, Stock L, Treptow W (2022). Comput and Struct Biotech J 20, 4885-4891.
Pontes C, Andrade M, Fiorote J, Treptow W (2021). Sci Rep 11, 6902.
Coevolutive, Evolutive and Stochastic Information in Protein-Protein Interactions
Binding of the general anesthetic sevoflurane to ion channels
Stock L, Hosoume J, Cirqueira L, Treptow W (2018). PLoS Comput Biol 14: e1006605.
Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins
Stock, L., Hosoume, J., & Treptow, W. (2017). Sci Rep 7, 5734.
Electric fingerprint of voltage sensor domains
Souza, C. S., Amaral, C., & Treptow, W. (2014). PNAS 111, 17510-17515.
Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations
Delemotte, L., Tarek, M., Klein, M. L., Amaral, C., & Treptow, W. (2011). PNAS 108, 6109-6114.
Initial Response of the Potassium Channel Voltage Sensor to a Transmembrane Potential
Treptow, W., Tarek, M., & Klein, M. L. (2009). JACS 131, 2107-2109.
